From the hills of West Virginia, Amos McCoy moves his family to an inherited farm in California. Grandpa Amos is quick to give advice to his three grandchildren and wonders how his neighbors ever managed without him around.
TV-PG. Grandpa, Luke, Kate, Hassie and Little Luke McCoy travel from Smokey Corners, West Virginia to California. They take over an inherited farm and everyone loves it, but Grandpa has trouble adjusting to the new place.
TV-PG. Grandpa gets into an egg feud with a rival egg salesman. He makes money, but the rest of the family suffers when Hassie wants to date the rival's son.
TV-PG. Grandpa and Luke need a new gun for a shooting contest, and Kate needs a new dress to be inducted into the PTA. But, there's just enough money in the cookie jar for one of them.
TV-PG. The McCoys find out that they are three months behind on their mortgage payments and will lose the farm if they can't come up with the money. Grandpa fears that he will have to sell a 200 year old flintlock family rifle to get the payment.
TV-PG. Kate wants to discipline Hassie and Little Luke for bad grades and skipping school, but Grandpa thinks she is being too tough, so Kate lets Grandpa takes over raising the kids.
TV-PG. Grandpa's innate honesty saves the day when a dishonest real estate speculator tries to buy five unproductive acres of the McCoys' land for considerably less than its actual value.
TV-PG. Kate pointedly tells Luke that he is welcome to go fishing with Grandpa and Mac Maginnis and to do whatever he wishes for several nights thereafter, but Grandpa steps in to make amends when he realizes that Luke's "freedom" is causing a genuine strain on their still-young marriage.
TV-PG. The Farmer's Association is having it's fall dance and Grandpa doesn't want to take Flora MacMichael until Little Luke tells him about the box supper that Flora is bringing.
TV-PG. Grandpa and George MacMichael compete to win the fishing contest. The only problem is that both of them are better at cheating than fishing.
TV-PG. Grandpa pretends to be able to read so he can vote against an uppity female politician.
TV-PG. Grandpa gets struck with jealousy because of Flora MacMichael and tries to take it out on her apple tree.
TV-PG. Grandpa and Luke jeopardize Kate's chances to be named to a church committee when they unwittingly allow a Las Vegas gambling house to advertise on the McCoys' barn.
TV-PG. Much to Grampa's consternation, George wants to join a private club known as the Loyal Order of the Mystic Nile.
TV-PG. Grampa's vanity gets the best of him when he refuses to acknowledge that he needs eyeglasses to pass the vision test for his new California driver's license.
TV-PG. A multi-talented photographer obtains the McCoys' permission to take pictures of their farm, but Luke becomes jealous when he seems to be focusing most of his attention on Kate.
TV-PG. Grandpa has Luke prepared for the worst when it is learned that Kate's mother is coming for a visit, but everyone is surprised when she arrives and repeatedly chides Kate for being insufficiently attentive to Luke's needs.
TV-PG. Grandpa trades a date with Flora for a hound dog.
TV-PG. Amos invites their old neighbors to California for a visit including Luke's old girlfriend Elvira. Kate tries to hide her jealousy during the reminiscing of old times.
TV-PG. When some of Little Luke's classmates tease and bully him about his "hillbilly" roots, Grandpa steps in to teach them about the perniciousness of prejudice.
TV-PG. The retirement of the postman convinces Luke and Kate that Grandpa Amos should take it easier. It backfires when Grandpa instead works too hard and ends up bedridden.
TV-PG. Grampa breaks up Flora's romance, and is forced to propose to her.
TV-PG. After one full year of marriage, Luke and Kate finally get to go on their honeymoon.
TV-PG. Luke is tricked into buying a swimming pool.
TV-PG. Kate's rich Uncle Dave stays with the McCoys for the weekend.